About: CYP46A1|CYP46A1

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An Entity of Type : about:10858#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
type	gngm Semmed Gene CYP46A1\|CYP46A1
label	CYP46A1\|CYP46A1 CYP46A1 cholesterol 24-hydroxylase\|CYP46A1 CYP46A1 gene\|CYP46A1
sameAs	CYP46A1 gene\|CYP46A1 (NIH - Gene)
terms:part_of	Brain Human macrophage House mice Elderly Hepatic Microglial Lambda
terms:isa	Therapeutic procedure Enzymes Cytochrome P450 Mixed Function Oxygenases cholesterol 24-hydroxylase CYP46A1\|CYP46A1
terms:causes	Dissociation Alzheimer's Disease
terms:location_of	Transcription, Genetic Polymorphism, Genetic mRNA Expression derepression
terms:produces	Metabolites
terms:interacts_with	Cells Cholesterol Neurons Proteins Astrocytes Acetyl-CoA Carboxylase Retinal Ganglion Cells HMGCR gene\|HMGCR 24-hydroxycholesterol Cholestanol
terms:affects	Brain Neostriatum Neuroprotection Equilibrium Cerebral cortex Impaired cognition Alzheimer's Disease Aging Neuraxis Hydroxylation Metabolic syndrome Cholesterol Homeostasis Entire putamen beta-amyloid metabolism histone deacetylase binding
terms:coexists_with	Apolipoprotein E\|APOE
terms:inhibits	liver X receptor CYP46A1\|CYP46A1
terms:stimulates	Binding Protein Cholesterol Neurons Phosphorylation Isoprenoids 24-hydroxycholesterol Cholestanol Glial Fibrillary Acidic Protein\|GFAP
terms:associated_with	Pathogenesis Huntington Disease Glaucoma Neurodegenerative Disorders Memory impairment Alzheimer's Disease Diabetes Mellitus, Non-Insulin-Dependent Alzheimer Disease, Late Onset Cataract Cognitive deterioration
terms:prevents	Atrophic
terms:predisposes	Alzheimer's Disease
terms:neg_affects	Cerebellum Entire hippocampus Alzheimer's Disease
terms:disrupts	Nerve Degeneration
terms:augments	Liver Brain Retina Transcription, Genetic Chromosome Pairing
terms:neg_coexists_with	ABCB1 gene\|ABCB1 Apolipoprotein E\|APOE COMPLEMENT FACTOR H\|CFH
terms:neg_interacts_with	COG2
terms:neg_augments	Brain
terms:neg_predisposes	Alzheimer's Disease
schema:identifier	C1435821\|10858 C0769789\|10858 10858 C1413885\|10858
is type of	CYP46A1\|CYP46A1
is sameAs of	CYP46A1\|CYP46A1 cholesterol 24-hydroxylase CYP46A1 gene\|CYP46A1

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