About: ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)

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About: ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) Goto Sponge NotDistinct Permalink

An Entity of Type : about:orch#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
type	phsu orch
label	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) ((3z)-n-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1h-pyrrol-2-yl)methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide)
http://semmed.demo...ksw.com/terms#isa	Pharmaceutical Preparations Sulfonamides
http://semmed.demo...com/terms#affects	Cells Cell Cycle Carcinoma of the Large Intestine
http://semmed.demo...rms#coexists_with	Pharmaceutical Preparations SN 38
http://semmed.demo...rms#compared_with	Pharmaceutical Preparations Agent
http://semmed.demo...om/terms#inhibits	Phospholipase C TOP1 gene\|TOP1 Cyclin D1\|CCND1 HLF
http://semmed.demo.../terms#stimulates	Protein-tyrosine kinase inhibitor
http://semmed.demo...terms#higher_than	Agent
http://semmed.demo...terms#neg_affects	Cells Cell Line
http://semmed.demo...om/terms#disrupts	Phosphorylation
http://semmed.demo...om/terms#augments	G1 Arrest
terms:isa	Pharmaceutical Preparations Sulfonamides
terms:causes	Apoptosis Cell Death Autophagy Programmed Cell Death, Type II
terms:interacts_with	Hepatocyte Growth Factor\|HGF Proto-Oncogene Proteins c-akt\|AKT1 Green Fluorescent Proteins MET gene Proto-Oncogene Proteins c-akt\|AKT1 Hepatocyte Growth Factor\|HGF
terms:affects	Cells Cell Line Growth Cell Growth Cell Cycle Tumor cells, malignant Maximum MAP kinase kinase activity Autophagy kinase activity Carcinoma of the Large Intestine Cancer Cell Growth
terms:treats	Malignant neoplasm of lung melanoma Rhabdomyosarcoma Xenograft Model Plasmacytoma
terms:coexists_with	Pharmaceutical Preparations Hepatocyte Growth Factor\|HGF bortezomib SN 38 lenalidomide Hepatocyte Growth Factor\|HGF
terms:compared_with	Therapeutic procedure Pharmaceutical Preparations Agent
terms:inhibits	UDP-Glucuronosyltransferase 1A1\|UGT1A1 Reactive Oxygen Species Fibronectins Phosphotransferases cyclooxygenase 2 Growth Factor Receptors 1-Phosphatidylinositol 3-Kinase Epidermal Growth Factor Receptor small molecule Phospholipase C TOP1 gene\|TOP1 Cyclin D1\|CCND1 CCND1 gene\|CCND1 ABCG2 gene\|ABCG2 MET gene Phospholipase C\|HSPG2 UDP-Glucuronosyltransferase 1A1\|UGT1A Proto-Oncogene Protein c-met Glycine dehydrogenase (decarboxylating) HGF gene\|HGF Carbon Black IDO1 HLF Hepatocyte Growth Factor\|HGF TOP1 gene\|TOP1 ABCG2 gene\|ABCG2
terms:stimulates	Reactive Oxygen Species TP53 gene\|TP53 Protein p53\|TP53 Transaminases Osteocalcin Alkaline Phosphatase RUNX2 Protein-tyrosine kinase inhibitor TP53 gene\|TP53
terms:neg_treats	No past history
terms:higher_than	Agent
terms:neg_affects	Cells Cell Line

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