About: EWS-FLI1 fusion protein|FLII

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An Entity of Type : about:c0908880#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
type	EWS-FLI1 fusion protein\|FLII
label	EWS-FLI1 fusion protein\|FLII fli1 EWS-FLI1 fusion protein\|FLI1\|FLII EWS-FLI1 fusion protein\|EWSR1 ewsr1 flii ews-fli1 fusion protein
sameAs	FLI1 FLI1\|FLII EWS-ETS\|EWSR1
terms:part_of	Cell Line, Tumor Ewings sarcoma
terms:isa	TRANSCRIPTION FACTOR
terms:causes	Disease Malignant Neoplasms Neoplasm Up-Regulation (Physiology) Hepatomegaly Growth arrest Ewings sarcoma Neuroectodermal Tumors
terms:location_of	Transcription, Genetic Transfection DNA Binding attenuation Ectopic Expression
terms:produces	Fusion Protein
terms:interacts_with	Cells MicroRNAs Interleukin-6 Carcinogens Binding Sites Fibroblasts CREBBP protein, human\|CREBBP Chromatin Enhancer CDKN1A\|TCEAL1\|NSG1\|H3F3AP6 Tenascin Transcription Repressor/Corepressor MYC gene\|MYC Insulin-Like Growth Factor Binding Protein 3 neuroblastoma cell Transcription Coactivator SOX2 ID2 gene\|ID2 ETS1 gene\|ETS1 FLI1 CDKN1C gene\|CDKN1C MIRN145 gene\|MIR145 MIRN145 gene\|MIR145
terms:affects	Growth Transcription, Genetic cytotoxicity Gene Activation Neuronal Differentiation mesoderm cell differentiation
terms:inhibits	multicatalytic endopeptidase complex Proteins TP53 gene\|TP53 Somatomedins FOXO1 DKK1 CDKN1C gene\|CDKN1C
terms:stimulates	Cells Fibroblast Growth Factor 2\|FGF2 c-myc Genes\|MYC GLI1 gene\|GLI1 PTCH1 REST gene
terms:associated_with	Ewings sarcoma Neuroectodermal Tumors Malignant Bone Neoplasm Sarcoma, Clear Cell
terms:neg_associated_with	Neuroblastoma
terms:disrupts	Growth tumor growth Growth arrest Normal growth
terms:augments	Ewings sarcoma
terms:administered_to	Human Cell Line
terms:neg_stimulates	EPHB2\|MAPK1
ASSOCIATED_WITH	Ewings sarcoma Malignant Bone Neoplasm
schema:identifier	2314 2313 C0908880\|2314 2130 C0908880\|2313\|2314 C0908880\|2130 c0908880
CAUSES	Disease Neoplasm Up-Regulation (Physiology) Hepatomegaly Ewings sarcoma
INTERACTS_WITH	Cells MicroRNAs MYC gene\|MYC SOX2

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