About: Checkpoint kinase 1

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An Entity of Type : about:c0216510#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
label	checkpoint kinase 1 chek1
sameAs	CHEK1 protein, human\|CHEK1
NEG_PART_OF	Malignant Neoplasms
LOCATION_OF	Mutation mRNA Expression
COEXISTS_WITH	Proliferating Cell Nuclear Antigen\|PCNA Chromatin Casein Kinase Idelta
NEG_AFFECTS	cell transformation
ASSOCIATED_WITH	Neoplasm Pancreatic carcinoma Malignant neoplasm of gastrointestinal tract Neuroblastoma Anemia Refractory anemias Glioblastoma medulloblastoma Bone marrow toxicity
schema:identifier	1111 c0216510
ISA	Phosphotransferases
INHIBITS	PARP1\|COL11A2 small molecule WEE1 CHES1 gene\|FOXN3 CDC2 Protein Kinase\|CDK1
PART_OF	Cells Cytoplasm Neoplasm Schizosaccharomyces pombe
CAUSES	Apoptosis Cell Proliferation DNA Damage Cell Cycle Arrest
INTERACTS_WITH	Cells Proteins Histones MERTK gene\|MERTK SYK protein, human\|SYK SYK gene\|SYK Histone H2a CHES1 gene\|FOXN3 Antimetabolites CDC25C\|RASGRF1 UCN 01
STIMULATES	TP53 gene\|TP53 Phosphotransferases Phosphorylation RNA Synthesis PRTN3 gene\|PRTN3
AFFECTS	Cells DNA biosynthesis Apoptosis [M]Unspecified tumor cell NOS Cell Death Cell Cycle Signal Transduction Tumor cells, malignant DNA Repair Receptor Signaling Hematopoiesis DNA damage checkpoint Genomic Stability Cell Cycle Checkpoint Normal hematopoiesis
compared_with	Binding Protein
PREDISPOSES	tumor growth
PREVENTS	Leukemia, Myelocytic, Acute
DISRUPTS	Malignant Neoplasms Growth tumor growth Tumor cells, malignant Toxic effect DNA Damage Sensitization Cell Cycle Arrest
AUGMENTS	Apoptosis Neoplasm Cell Death cytotoxicity replication fork Lesion of cervix
PRODUCES	H2AX protein, human\|H2AFX
NEG_ISA	Therapeutic procedure
NEG_STIMULATES	Colcemide Poisons
NEG_DISRUPTS	Cells DNA biosynthesis Mediated Responses
is NEG_LOCATION_OF of	Cells
is LOCATION_OF of	Cells Cell Nucleus C0030705 Cell Line [M]Unspecified tumor cell NOS Mus Clone Cells Bone Marrow Cells network

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