About: eIF-2 Kinase|PKLR|EIF2AK2

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An Entity of Type : about:c0058980#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
label	ddx5 eif-2 kinase pklr eif2ak2 khdrbs1 eif2ak1 pold3 gatad2b
sameAs	DDX5\|KHDRBS1\|POLD3\|GATAD2B PKLR\|PROK1 oncogene protein DBL\|POLD3 KHDRBS1 GATAD2B EIF2AK1 PRKR gene\|EIF2AK2
NEG_PART_OF	Cells
LOCATION_OF	Evolution Transcriptional Activation RNA Binding mRNA Expression Translational Regulation
COEXISTS_WITH	VEGF protein, human\|VEGFA Interleukin-6 RNA Tumor Suppressor Genes RNA, Double-Stranded Interferons Interferon Alpha, Human\|IFNA1 YEAST EXTRACT STAT5A protein, human\|STAT5A Activating Transcription Factors Isopropyl Thiogalactoside RBBP6\|PRKRA DNAJC3
NEG_AFFECTS	Phosphorylation Dominant-Negative Mutation Covalent Interaction
NEG_ASSOCIATED_WITH	Neoplasm Metabolic Diseases
ASSOCIATED_WITH	Functional disorder Oxidative Stress Neoplasm Carcinoma Alzheimer's Disease Hematologic Neoplasms Diabetes Mellitus, Non-Insulin-Dependent Insulin Resistance Neuroblastoma Hypersensitivity Cellular Stress DELETION Chronic inflammation Viral Pathogenesis Carcinoma, Papillary
schema:identifier	1655 10714 10657 57459 5313 27102 5610 c0058980
ISA	Therapeutic procedure Proteins Phosphotransferases PROTEIN KINASE Protein-Serine-Threonine Kinases Therapeutic agent (substance)
INHIBITS	DNA Sequence multicatalytic endopeptidase complex CRK protein, human\|CRK NF-kappa B Hydrogen Peroxide c-myc Genes\|MYC human leukocyte interferon\|IFNA1 RNA, Double-Stranded Interferon Alpha, Human\|IFNA1 Viral Proteins I Kappa B-Alpha Eukaryotic Initiation Factor-2\|EIF2S1\|EIF2S3\|EIF2S2 Eukaryotic Initiation Factor-2B ribonuclease L inhibitor\|RNASEL
PART_OF	host Cells Malignant Neoplasms C0030705 Liver Brain Human Protoplasm Population Group House mice Zebrafish Fishes integral to membrane Mammalian Cell Hepatitis C virus nucleocapsid location Lobe Entire diaphragm

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