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    ADGRB2 adhesion G protein-coupled receptor B2 [ Homo sapiens (human) ]

    Gene ID: 576, updated on 17-Jun-2024

    Summary

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    Official Symbol
    ADGRB2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:944
    See related
    Ensembl:ENSG00000121753 MIM:602683; AllianceGenome:HGNC:944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAI2
    Summary
    This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
    Expression
    Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRB2 in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31727117..31764340, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31584757..31621990, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32192718..32229941, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32110207-32110977 Neighboring gene penta-EF-hand domain containing 1 Neighboring gene PEF1 and COL16A1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32123622-32123860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32124291-32124792 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131402-32131941 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32131942-32132480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32133021-32133558 Neighboring gene uncharacterized LOC101929444 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:32145564-32146763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32147039-32147911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32162063-32162572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32164717-32165470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32166977-32167729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 649 Neighboring gene Sharpr-MPRA regulatory region 11964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32181521-32182116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32189409-32189910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32218779-32219393 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32219394-32220007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32220374-32220980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32221586-32222191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32222192-32222796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32227559-32228412 Neighboring gene uncharacterized LOC124903930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 576 Neighboring gene microRNA 4254 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:32253763-32254538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 578 Neighboring gene SPOC domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. Zencir S, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21787750, Free PMC Article
    2. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. Jeong BC, et al. FEBS Lett, 2006 Jan 23. PMID 16412436
    3. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Shiratsuchi T, et al. Cytogenet Cell Genet, 1997. PMID 9533023
    4. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Purcell RH, et al. Hum Mutat, 2017 Dec. PMID 28891236, Free PMC Article
    5. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. Okajima D, et al. J Recept Signal Transduct Res, 2010 Jun. PMID 20367554

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies provide new insights into the signaling capabilities of the adhesion GPCR BAI2/ADGRB2 and shed light on how an apparent gain-of-function mutation to the receptor's C-terminus may lead to human disease.
      Title: A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity.
    2. This is the first study reporting BAI2 as an interaction partner of GIP.
      Title: Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    4. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway
      Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.
    5. involvement of BAI2 in the ischemia-induced brain angiogenesis
      Title: Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor B2
    Names
    brain-specific angiogenesis inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001294335.2 → NP_001281264.1  adhesion G protein-coupled receptor B2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001281264.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
      Source sequence(s)
      AB005298, AC114488, AI291691, AL354919, DA494051
      Consensus CDS
      CCDS72747.1
      UniProtKB/TrEMBL
      A2A3C2
      Related
      ENSP00000362759.2, ENST00000373655.6
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:929 → 1198
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:615 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. NM_001294336.2 → NP_001281265.1  adhesion G protein-coupled receptor B2 isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB005298, AC114488, AI291691, AL354919, BC136533, DA494051
      Consensus CDS
      CCDS72746.1
      UniProtKB/TrEMBL
      A2A3C2
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:929 → 1165
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:615 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    3. NM_001364857.2 → NP_001351786.1  adhesion G protein-coupled receptor B2 isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC114488, AL354919
      Consensus CDS
      CCDS346.2
      UniProtKB/Swiss-Prot
      B9EGK9, O60241, Q5T6K0, Q8NGW8, Q96GZ9
      UniProtKB/TrEMBL
      A2A3C2
      Related
      ENSP00000362762.3, ENST00000373658.8
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam16489
      Location:614 → 771
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15988
      Location:929 → 1219
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      31727117..31764340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541858.3 → XP_011540160.1  adhesion G protein-coupled receptor B2 isoform X26

      UniProtKB/TrEMBL
      B4DKC3
      Conserved Domains (5) summary
      smart00303
      Location:567 → 620
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:228 → 292
      HormR; Domain present in hormone receptors
      smart00209
      Location:64 → 114
      TSP1; Thrombospondin type 1 repeats
      cd15988
      Location:626 → 916
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam16489
      Location:311 → 466
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    2. XM_047426187.1 → XP_047282143.1  adhesion G protein-coupled receptor B2 isoform X20

      UniProtKB/TrEMBL
      A2A3C6

    3. XM_047426186.1 → XP_047282142.1  adhesion G protein-coupled receptor B2 isoform X18

      UniProtKB/TrEMBL
      A2A3C6

    4. XM_047426180.1 → XP_047282136.1  adhesion G protein-coupled receptor B2 isoform X11

      UniProtKB/TrEMBL
      A2A3C3

    5. XM_047426178.1 → XP_047282134.1  adhesion G protein-coupled receptor B2 isoform X7

      UniProtKB/TrEMBL
      A2A3C2

    6. XM_017001899.2 → XP_016857388.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/Swiss-Prot
      B9EGK9, O60241, Q5T6K0, Q8NGW8, Q96GZ9
      UniProtKB/TrEMBL
      A2A3C2
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam16489
      Location:614 → 771
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15988
      Location:929 → 1219
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    7. XM_047426181.1 → XP_047282137.1  adhesion G protein-coupled receptor B2 isoform X11

      UniProtKB/TrEMBL
      A2A3C3

    8. XM_047426173.1 → XP_047282129.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/Swiss-Prot
      B9EGK9, O60241, Q5T6K0, Q8NGW8, Q96GZ9
      UniProtKB/TrEMBL
      A2A3C2

    9. XM_047426188.1 → XP_047282144.1  adhesion G protein-coupled receptor B2 isoform X23

      UniProtKB/TrEMBL
      A2A3C1, A2A3C3
      Related
      ENSP00000381550.1, ENST00000398542.5

    10. XM_047426185.1 → XP_047282141.1  adhesion G protein-coupled receptor B2 isoform X17

      UniProtKB/TrEMBL
      A2A3C2

    11. XM_047426184.1 → XP_047282140.1  adhesion G protein-coupled receptor B2 isoform X16

      UniProtKB/TrEMBL
      A2A3C2

    12. XM_017001903.2 → XP_016857392.1  adhesion G protein-coupled receptor B2 isoform X6

      UniProtKB/TrEMBL
      A2A3C2

    13. XM_017001902.2 → XP_016857391.1  adhesion G protein-coupled receptor B2 isoform X5

      UniProtKB/TrEMBL
      A2A3C2

    14. XM_017001909.2 → XP_016857398.1  adhesion G protein-coupled receptor B2 isoform X14

      UniProtKB/TrEMBL
      A2A3C3
      Related
      ENSP00000381555.1, ENST00000398547.5
      Conserved Domains (5) summary
      smart00303
      Location:815 → 868
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 540
      HormR; Domain present in hormone receptors
      smart00209
      Location:312 → 362
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:874 → 1143
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:560 → 717
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    15. XM_047426190.1 → XP_047282146.1  adhesion G protein-coupled receptor B2 isoform X25

      UniProtKB/TrEMBL
      A2A3C6

    16. XM_047426189.1 → XP_047282145.1  adhesion G protein-coupled receptor B2 isoform X24

      UniProtKB/TrEMBL
      A2A3C6

    17. XM_047426183.1 → XP_047282139.1  adhesion G protein-coupled receptor B2 isoform X15

      UniProtKB/TrEMBL
      A2A3C3

    18. XM_047426179.1 → XP_047282135.1  adhesion G protein-coupled receptor B2 isoform X10

      UniProtKB/TrEMBL
      A2A3C2

    19. XM_017001900.2 → XP_016857389.1  adhesion G protein-coupled receptor B2 isoform X2

      UniProtKB/TrEMBL
      A2A3C2
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:929 → 1198
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:615 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    20. XM_017001901.2 → XP_016857390.1  adhesion G protein-coupled receptor B2 isoform X4

      UniProtKB/TrEMBL
      A2A3C2
      Related
      ENSP00000381548.1, ENST00000398538.5
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:929 → 1198
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:615 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    21. XM_024448673.2 → XP_024304441.1  adhesion G protein-coupled receptor B2 isoform X3

      UniProtKB/TrEMBL
      A2A3C2
      Conserved Domains (5) summary
      smart00303
      Location:858 → 911
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:519 → 583
      HormR; Domain present in hormone receptors
      smart00209
      Location:355 → 405
      TSP1; Thrombospondin type 1 repeats
      pfam16489
      Location:602 → 759
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cd15988
      Location:917 → 1207
      7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

    22. XM_017001911.2 → XP_016857400.1  adhesion G protein-coupled receptor B2 isoform X21

      UniProtKB/TrEMBL
      A2A3C6
      Conserved Domains (5) summary
      smart00303
      Location:815 → 868
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 540
      HormR; Domain present in hormone receptors
      smart00209
      Location:312 → 362
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:874 → 1110
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:560 → 717
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    23. XM_017001908.2 → XP_016857397.1  adhesion G protein-coupled receptor B2 isoform X12

      UniProtKB/TrEMBL
      A2A3C3
      Conserved Domains (5) summary
      smart00303
      Location:815 → 868
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 540
      HormR; Domain present in hormone receptors
      smart00209
      Location:312 → 362
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:874 → 1143
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:560 → 717
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    24. XM_047426182.1 → XP_047282138.1  adhesion G protein-coupled receptor B2 isoform X13

      UniProtKB/TrEMBL
      A2A3C3

    25. XM_017001905.2 → XP_016857394.1  adhesion G protein-coupled receptor B2 isoform X8

      UniProtKB/TrEMBL
      A2A3C2
      Related
      ENSP00000435397.1, ENST00000527361.5
      Conserved Domains (5) summary
      smart00303
      Location:870 → 923
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:531 → 595
      HormR; Domain present in hormone receptors
      smart00209
      Location:367 → 417
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:929 → 1165
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:615 → 772
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    26. XM_017001906.2 → XP_016857395.1  adhesion G protein-coupled receptor B2 isoform X9

      UniProtKB/TrEMBL
      A2A3C2

    27. XM_017001912.2 → XP_016857401.1  adhesion G protein-coupled receptor B2 isoform X22

      UniProtKB/TrEMBL
      A2A3C3
      Conserved Domains (5) summary
      smart00303
      Location:760 → 813
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:421 → 485
      HormR; Domain present in hormone receptors
      smart00209
      Location:368 → 418
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:819 → 1088
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:505 → 662
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    28. XM_017001910.2 → XP_016857399.1  adhesion G protein-coupled receptor B2 isoform X19

      UniProtKB/TrEMBL
      A2A3C6
      Related
      ENSP00000381564.3, ENST00000398556.7
      Conserved Domains (5) summary
      smart00303
      Location:815 → 868
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476 → 540
      HormR; Domain present in hormone receptors
      smart00209
      Location:312 → 362
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:874 → 1110
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam16489
      Location:560 → 717
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

    29. XM_047426191.1 → XP_047282147.1  adhesion G protein-coupled receptor B2 isoform X27

      UniProtKB/TrEMBL
      A2A3C4
      Related
      ENSP00000410921.1, ENST00000420125.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      31584757..31621990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337889.1 → XP_054193864.1  adhesion G protein-coupled receptor B2 isoform X26

      UniProtKB/TrEMBL
      B4DKC3

    2. XM_054337883.1 → XP_054193858.1  adhesion G protein-coupled receptor B2 isoform X20

      UniProtKB/TrEMBL
      A2A3C6

    3. XM_054337881.1 → XP_054193856.1  adhesion G protein-coupled receptor B2 isoform X18

      UniProtKB/TrEMBL
      A2A3C6

    4. XM_054337874.1 → XP_054193849.1  adhesion G protein-coupled receptor B2 isoform X11

      UniProtKB/TrEMBL
      A2A3C3

    5. XM_054337870.1 → XP_054193845.1  adhesion G protein-coupled receptor B2 isoform X7

      UniProtKB/TrEMBL
      A2A3C2

    6. XM_054337864.1 → XP_054193839.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/Swiss-Prot
      B9EGK9, O60241, Q5T6K0, Q8NGW8, Q96GZ9
      UniProtKB/TrEMBL
      A2A3C2

    7. XM_054337863.1 → XP_054193838.1  adhesion G protein-coupled receptor B2 isoform X1

      UniProtKB/Swiss-Prot
      B9EGK9, O60241, Q5T6K0, Q8NGW8, Q96GZ9
      UniProtKB/TrEMBL
      A2A3C2

    8. XM_054337886.1 → XP_054193861.1  adhesion G protein-coupled receptor B2 isoform X23

      UniProtKB/TrEMBL
      A2A3C1, A2A3C3

    9. XM_054337880.1 → XP_054193855.1  adhesion G protein-coupled receptor B2 isoform X17

      UniProtKB/TrEMBL
      A2A3C2

    10. XM_054337879.1 → XP_054193854.1  adhesion G protein-coupled receptor B2 isoform X16

      UniProtKB/TrEMBL
      A2A3C2

    11. XM_054337869.1 → XP_054193844.1  adhesion G protein-coupled receptor B2 isoform X6

      UniProtKB/TrEMBL
      A2A3C2

    12. XM_054337868.1 → XP_054193843.1  adhesion G protein-coupled receptor B2 isoform X5

      UniProtKB/TrEMBL
      A2A3C2

    13. XM_054337877.1 → XP_054193852.1  adhesion G protein-coupled receptor B2 isoform X14

      UniProtKB/TrEMBL
      A2A3C3

    14. XM_054337888.1 → XP_054193863.1  adhesion G protein-coupled receptor B2 isoform X25

      UniProtKB/TrEMBL
      A2A3C6

    15. XM_054337887.1 → XP_054193862.1  adhesion G protein-coupled receptor B2 isoform X24

      UniProtKB/TrEMBL
      A2A3C6

    16. XM_054337878.1 → XP_054193853.1  adhesion G protein-coupled receptor B2 isoform X15

      UniProtKB/TrEMBL
      A2A3C3

    17. XM_054337873.1 → XP_054193848.1  adhesion G protein-coupled receptor B2 isoform X10

      UniProtKB/TrEMBL
      A2A3C2

    18. XM_054337865.1 → XP_054193840.1  adhesion G protein-coupled receptor B2 isoform X2

      UniProtKB/TrEMBL
      A2A3C2

    19. XM_054337867.1 → XP_054193842.1  adhesion G protein-coupled receptor B2 isoform X4

      UniProtKB/TrEMBL
      A2A3C2

    20. XM_054337866.1 → XP_054193841.1  adhesion G protein-coupled receptor B2 isoform X3

      UniProtKB/TrEMBL
      A2A3C2

    21. XM_054337884.1 → XP_054193859.1  adhesion G protein-coupled receptor B2 isoform X21

      UniProtKB/TrEMBL
      A2A3C6

    22. XM_054337875.1 → XP_054193850.1  adhesion G protein-coupled receptor B2 isoform X12

      UniProtKB/TrEMBL
      A2A3C3

    23. XM_054337876.1 → XP_054193851.1  adhesion G protein-coupled receptor B2 isoform X13

      UniProtKB/TrEMBL
      A2A3C3

    24. XM_054337871.1 → XP_054193846.1  adhesion G protein-coupled receptor B2 isoform X8

      UniProtKB/TrEMBL
      A2A3C2

    25. XM_054337872.1 → XP_054193847.1  adhesion G protein-coupled receptor B2 isoform X9

      UniProtKB/TrEMBL
      A2A3C2

    26. XM_054337885.1 → XP_054193860.1  adhesion G protein-coupled receptor B2 isoform X22

      UniProtKB/TrEMBL
      A2A3C3

    27. XM_054337882.1 → XP_054193857.1  adhesion G protein-coupled receptor B2 isoform X19

      UniProtKB/TrEMBL
      A2A3C6

    28. XM_054337890.1 → XP_054193865.1  adhesion G protein-coupled receptor B2 isoform X27

      UniProtKB/TrEMBL
      A2A3C4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60241.2 GenPept UniProtKB/Swiss-Prot:O60241

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