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    HNP1 Hypertensive nephropathy [ Homo sapiens (human) ]

    Gene ID: 574045, updated on 5-Nov-2023

    Summary

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    Gene symbol
    HNP1
    Gene description
    Hypertensive nephropathy
    Primary source
    MIM:608026
    Gene type
    unknown
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

    Genomic context

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    Location:
    9q31-q32

    Bibliography

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    Related articles in PubMed

    1. Aptamer selection against alpha-defensin human neutrophil peptide 1 on an integrated microfluidic system for diagnosis of periprosthetic joint infections. Gandotra R, et al. Lab Chip, 2022 Jan 18. PMID 34918728
    2. Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis. Ibusuki R, et al. PLoS One, 2017. PMID 28403148, Free PMC Article
    3. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. Paulin N, et al. EBioMedicine, 2017 Feb. PMID 28111237, Free PMC Article
    4. Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission. Valere K, et al. Viral Immunol, 2015 Dec. PMID 26379091, Free PMC Article
    5. Trp-26 imparts functional versatility to human alpha-defensin HNP1. Wei G, et al. J Biol Chem, 2010 May 21. PMID 20220136, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aptamer selection against alpha-defensin human neutrophil peptide 1 on an integrated microfluidic system for diagnosis of periprosthetic joint infections.
      Title: Aptamer selection against alpha-defensin human neutrophil peptide 1 on an integrated microfluidic system for diagnosis of periprosthetic joint infections.
    2. we engineered a monoclonal antibody against HNP-1 to block the interaction with P2X7 and found that the blocking antibody protected mice carrying high copy number of DEFA1/DEFA3 from lethal sepsis. We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information.
      Title: Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis.
    3. combined experimentally determined binding affinities (KD) of several orthologs of CCL5 with HNP1 with in silico studies to identify the most likely heterodimeric CCL5-HNP1 complex which was subsequently used as a starting structure to rationally design peptidic inhibitors
      Title: Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1).
    4. HNP-1 secreted by neutrophils may exacerbate alcohol-induced hepatic fibrosis and hepatocyte apoptosis with a decrease in Bcl2 expression and an increase in miR-34a-5p expression.
      Title: Human neutrophil peptide-1 promotes alcohol-induced hepatic fibrosis and hepatocyte apoptosis.
    5. Data show that mice with transgenic expression of human neutrophil peptide 1 (HNP1) exhibit lower plasma VLDL/LDL levels and smaller atherosclerotic lesion sizes.
      Title: Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance.
    6. High HNP1 expression is associated with IgA Nephropathy.
      Title: Elevated Plasma α-Defensins (HNP1-3) Levels Correlated with IgA1 Glycosylation and Susceptibility to IgA Nephropathy.
    7. These results suggest a role for HNP1 in sexually transmitted infections-mediated enhancement of HIV transmission
      Title: Human Alpha-Defensin HNP1 Increases HIV Traversal of the Epithelial Barrier: A Potential Role in STI-Mediated Enhancement of HIV Transmission.
    8. neutrophil-borne human neutrophil peptide 1 (HNP1, alpha-defensin) and platelet-derived CCL5 form heteromers.
      Title: Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5.
    9. the hydrophobicity of residue 26 is not only a key determinant of the direct interactions of HNP1 with target molecules, but it also governs the ability of this peptide to form dimers and more complex quaternary structures at micromolar concentrations.
      Title: Trp-26 imparts functional versatility to human alpha-defensin HNP1.
    10. these data suggest that SgIII, DMT-1 and HNP-1 are implicated in cell-mediated LDL oxidation.
      Title: LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Hypertensive nephropathy

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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