PROKR1 prokineticin receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PROKR1provided by HGNC
Official Full Name: prokineticin receptor 1provided by HGNC
Primary source: HGNC:HGNC:4524
See related: Ensembl:ENSG00000169618 MIM:607122; AllianceGenome:HGNC:4524
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZAQ; PKR1; GPR73; PK-R1; GPR73a
Summary: This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
Expression: Biased expression in fat (RPKM 1.4), adrenal (RPKM 0.7) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p13.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (68643579..68658251)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (68655911..68670584)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (68870711..68885383)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
The role of prokineticins in recurrent implantation failure.
Title: The role of prokineticins in recurrent implantation failure.
Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
Title: Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
PROK-1 and its receptors are involved in the pathogenesis and development of endometriosis
Title: [Expression of PROK 1 and its receptor PROKR 1 in endometriosis and its clinical significance].
a significant association between PKR2 rs6053283 polymorphism and Recurrent pregnancy loss (RPL)(P=0.003), whereas no association was observed between PKR1 rs4627609 polymorphism and RPL (P=0.929) in the Chinese Han population.
Title: Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.
Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW]
Title: Prokineticins in central and peripheral control of human reproduction.
EG-VEGF and its receptor PKR1 might play a role in the pathogenesis of adrenocortical tumors and could serve as prognostic markers for this rare malignant disease.
Title: Role of Endocrine Gland-Derived Vascular Endothelial Growth Factor (EG-VEGF) and Its Receptors in Adrenocortical Tumors.
Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk).
Title: Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
Study corroborates the clinical relevance of the EG-VEGF system in human early pregnancy, and provides evidence for the gene-gene interactions of EG-VEGF and PROKR variants.
Title: Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.
I397V variant confers lower risk for recurrent miscarriage
Title: Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481076

GPR73_2559 (e-PCR)
- UniSTS:280734

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prokineticin receptor 1

Names: G protein-coupled receptor 73; G protein-coupled receptor ZAQ

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051312.1 RefSeqGene

Range

5001..16989

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_138964.4 → NP_620414.1 prokineticin receptor 1

See identical proteins and their annotated locations for NP_620414.1

Status: REVIEWED

Source sequence(s)

AC105054

Consensus CDS

CCDS1889.1

UniProtKB/Swiss-Prot

A5JUU2, Q53QT9, Q8NFJ7, Q8TCW9

UniProtKB/TrEMBL

A0A7I2V3D2

Related

ENSP00000303775.4, ENST00000303786.5

Conserved Domains (1) summary

cd15204
Location:63 → 353

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors