About: aggrecanase-1|ACAN

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An Entity of Type : about:c0768063#this, within Data Space : semmed.demo.openlinksw.com associated with source document(s)

Attributes	Values
type	aapp gngm aggrecanase-1\|ACAN
label	aggrecanase-1\|ACAN aggrecanase-1 acan
sameAs	aggrecan\|ACAN
http://semmed.demo...s#associated_with	Laryngeal Squamous Cell Carcinoma
terms:causes	Degenerative polyarthritis
terms:location_of	mRNA Expression
terms:produces	Enzymes FRAGMENTS
terms:interacts_with	Glycosaminoglycans Mammalian Cell Synoviocytes TGFB1 protein, human\|TGFB1 aggrecan\|ACAN Protein C Inhibitor TGFB1 gene\|TGFB1 aggrecan\|ACAN
terms:affects	Hypoxia Degenerative polyarthritis Arthropathies NOS Abrasion
terms:coexists_with	Minocycline Tetracycline MSC gene\|MSC Immunoglobulin D MSC Doxycyline
terms:inhibits	aggrecan\|ACAN Interstitial Collagenase collagenase 3 aggrecan\|ACAN brevican brevican\|BCAN
terms:stimulates	Chondrocytes
terms:associated_with	Degenerative polyarthritis Aortic Aneurysm, Thoracic Laryngeal Squamous Cell Carcinoma Lyme Arthritis
terms:disrupts	Cartilage
terms:augments	Chondrocytes Cartilage Cartilage formation
terms:administered_to	Chondrocytes Bone Marrow Stem Cell
terms:neg_inhibits	Endopeptidases
COEXISTS_WITH	Minocycline Tetracycline MSC gene\|MSC Doxycyline
ASSOCIATED_WITH	Lyme Arthritis
schema:identifier	176 C0768063\|176 C0768063 c0768063
INHIBITS	brevican
INTERACTS_WITH	TGFB1 protein, human\|TGFB1
STIMULATES	Chondrocytes
DISRUPTS	Cartilage
PRODUCES	Enzymes FRAGMENTS
is type of	aggrecanase-1\|ACAN
is http://semmed.demo...terms#location_of of	Cells Cartilage
is http://semmed.demo...om/terms#inhibits of	Hydantoin
is terms:part_of of	RNA, Messenger 5' Flanking Region Thrombospondin 1\|THBS1 Thrombospondins
is terms:location_of of	Cells Fibroblasts Chondrocytes Control Groups Cartilage Synovial Fluid
is terms:produces of	Cells Cytokinesis of the fertilized ovum Chondrocytes aggrecan\|ACAN aggrecan\|ACAN
is terms:interacts_with of	MicroRNAs VEGFA aggrecan\|ACAN SOCS1 Protein C Inhibitor Stromelysin 1 DISC1 DISC1 gene\|DISC1
is terms:inhibits of	Proteoglycan Interleukin-1 beta Hydantoin Glucosamine TIMP3 protein, human\|TIMP3 aggrecan\|ACAN Sulfonamides rhein beta-cryptoxanthin TIMP3 protein, human\|TIMP3

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