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    ERVK-18 endogenous retrovirus group K member 18 [ Homo sapiens (human) ]

    Gene ID: 100775105, updated on 7-Mar-2021

    Summary

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    Official Symbol
    ERVK-18provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 18provided by HGNC
    Primary source
    HGNC:HGNC:39025
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; env; c1_C; HERV-K18; Protease; Proteinase
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    Genomic context

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    Location:
    1q23.3

    Bibliography

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    Related articles in PubMed

    1. Expression of human endogenous retrovirus HERV-K18 is associated with clinical severity in osteoarthritis patients. Garcia-Montojo M, et al. Scand J Rheumatol, 2013. PMID 23662747
    2. Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta-analysis. de la Hera B, et al. PLoS One, 2013. PMID 23634223, Free PMC Article
    3. Association of human endogenous retrovirus K-18 polymorphisms with type 1 diabetes. Marguerat S, et al. Diabetes, 2004 Mar. PMID 14988274
    4. Autoantibodies to human endogenous retrovirus-K are frequently detected in health and disease and react with multiple epitopes. Herve CA, et al. Clin Exp Immunol, 2002 Apr. PMID 11982593, Free PMC Article
    5. Human endogenous retrovirus IDDMK(1,2)22 and mouse mammary tumor virus superantigens differ in their ability to stimulate murine T cell hybridomas. Azar GA, et al. Immunol Lett, 2002 Apr 1. PMID 11841850

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level.
      Title: Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level.
    2. downregulation of expression in the skin from Lichen planus patients
      Title: Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of patients with lichen planus.
    3. Expression of human endogenous retrovirus HERV-K18 is associated with clinical severity in osteoarthritis patients.
      Title: Expression of human endogenous retrovirus HERV-K18 is associated with clinical severity in osteoarthritis patients.
    Submit: New GeneRIF Correction

    General gene information

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    Other Names

    • Endogenous retrovirus group K member 18 Pro protein
    • Envelope polyprotein
    • HERV-K(C1a) Pro protein
    • HERV-K110 Pro protein
    • HERV-K18 Pro protein
    • HERV-K_1q23.3 provirus ancestral Env polyprotein
    • HERV-K_1q23.3 provirus ancestral Pol protein
    • HERV-K_1q23.3 provirus ancestral Pro protein
    • IDDMK1,2 22 envelope protein
    • IDDMK1,2 22 superantigen
    • IDDMK1,2-22
    • endogenous retrovirus K-18
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42043.2 GenPept UniProtKB/Swiss-Prot:O42043
    P63123.1 GenPept UniProtKB/Swiss-Prot:P63123

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