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    CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]

    Gene ID: 3579, updated on 13-May-2024

    Summary

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    Official Symbol
    CXCR2provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:6027
    See related
    Ensembl:ENSG00000180871 MIM:146928; AllianceGenome:HGNC:6027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD182; IL8R2; IL8RA; IL8RB; CMKAR2; WHIMS2; CDw128b
    Summary
    The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
    Expression
    Biased expression in appendix (RPKM 20.0), spleen (RPKM 13.2) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CXCR2 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218125294..218137251)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (218610987..218622946)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (218990017..219001974)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tensin 1 Neighboring gene uncharacterized LOC124907982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12309 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218890081-218890996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:218896372-218896928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899047-218899580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218899581-218900113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218910221-218910722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218930441-218930983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218933725-218934588 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:218940751-218941252 Neighboring gene C-X-C motif chemokine receptor 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:219039587-219040086 Neighboring gene small nucleolar RNA U13 Neighboring gene C-X-C motif chemokine receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19. Rice CM, et al. Life Sci Alliance, 2023 Feb. PMID 36622345, Free PMC Article
    2. CXC- receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain. Qiu C, et al. J Cell Mol Med, 2022 Dec. PMID 36349481, Free PMC Article
    3. Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease. Yao Z, et al. Front Immunol, 2022. PMID 35795659, Free PMC Article
    4. Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro. Wang H, et al. J Neuroinflammation, 2022 Jun 29. PMID 35768823, Free PMC Article
    5. CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma. Yamamoto Y, et al. PLoS One, 2022. PMID 35377900, Free PMC Article

    See all (402) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.
      Title: CXCR2/Snail-1-Induced Epithelial-Mesenchymal Transition in the Formation and Progression of RCC with Inferior Vena Cava Tumour Thrombus.
    2. VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.
      Title: VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.
    3. CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
      Title: CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis.
    4. Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-kappaB signaling in diabetic kidney disease.
      Title: Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease.
    5. Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.
      Title: Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation.
    6. Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
      Title: Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.
    7. IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
      Title: IL-8 is a novel prometastatic chemokine in intrahepatic cholangiocarcinoma that induces CXCR2-PI3K/AKT signaling upon CD97 activation.
    8. CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
      Title: CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A.
    9. IL8 derived from macrophages inhibits CD8[+] T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.
      Title: IL8 derived from macrophages inhibits CD8(+) T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer.
    10. IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
      Title: IL-8-induced CXCR2 down-regulation in circulating monocytes in hepatocellular carcinoma is partially dependent on MAGL.
    Submit: New GeneRIF Correction See all GeneRIFs (298)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    WHIM syndrome 2
    MedGen: C5543622 OMIM: 619407 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef induces variable levels of CXCR2 downregulation in different cell types in an ubiquitin-independent manner PubMed
    capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
    matrix gag HIV-1 MA interacts with CXCR2 in primary hepatocytes PubMed
    gag Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes upregulate the expression of CXCR2 receptor, which binds HIV-1 MA and its natural variant S75X, and enhances their internalization in cells PubMed
    gag HIV-1 MA-induced upregulation of collagen-I and alpha-SMA expression is dependent on CXCR2 via the Rho/ROCK-1 pathway PubMed
    gag Treatment of human stellate cells with HIV-1 MA upregulates the expression of CXCR2, syndecan-2, collagen-I, alpha-SMA, vimentin, and endothelin-1 PubMed
    gag HIV-1 MA and SIV MA induce migration of CXCR2-expressing B cells and Jurkat cells PubMed
    gag Surface plasmon resonance (SPR) binding assay demonstrates that SIV MA binds CXCR2 with higher affinity than HIV-1 MA binds CXCR2 PubMed
    gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-X-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables interleukin-8 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables interleukin-8 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular defense response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in interleukin-8-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutrophil activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mast cell granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    C-X-C chemokine receptor type 2
    Names
    CXC-R2
    CXCR-2
    CXCR2 gene for IL8 receptor type B
    GRO/MGSA receptor
    IL-8 receptor type 2
    IL-8R B
    chemokine (CXC) receptor 2
    high affinity interleukin-8 receptor B
    interleukin 8 receptor type 2
    interleukin 8 receptor, beta
    interleukin-8 receptor type B

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052975.1 RefSeqGene

      Range
      5739..16962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001168298.2 → NP_001161770.1  C-X-C chemokine receptor type 2

      See identical proteins and their annotated locations for NP_001161770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124768, AJ710879, DA674925
      Consensus CDS
      CCDS2408.1
      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49 → 325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001557.4 → NP_001548.1  C-X-C chemokine receptor type 2

      See identical proteins and their annotated locations for NP_001548.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC124768, L19593
      Consensus CDS
      CCDS2408.1
      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Related
      ENSP00000319635.2, ENST00000318507.7
      Conserved Domains (1) summary
      cd15178
      Location:49 → 325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      218125294..218137251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444190.1 → XP_047300146.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    2. XM_047444189.1 → XP_047300145.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    3. XM_047444187.1 → XP_047300143.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    4. XM_047444191.1 → XP_047300147.1  C-X-C chemokine receptor type 2 isoform X2

    5. XM_005246530.4 → XP_005246587.1  C-X-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_005246587.1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49 → 325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_047444188.1 → XP_047300144.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    7. XM_017003991.2 → XP_016859480.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
      Conserved Domains (1) summary
      cd15178
      Location:49 → 325
      7tmA_CXCR1_2; CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      218610987..218622946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341825.1 → XP_054197800.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    2. XM_054341823.1 → XP_054197798.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    3. XM_054341824.1 → XP_054197799.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    4. XM_054341821.1 → XP_054197796.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4

    5. XM_054341826.1 → XP_054197801.1  C-X-C chemokine receptor type 2 isoform X2

    6. XM_054341822.1 → XP_054197797.1  C-X-C chemokine receptor type 2 isoform X1

      UniProtKB/Swiss-Prot
      P25025, Q8IUZ1, Q9P2T6, Q9P2T7
      UniProtKB/TrEMBL
      Q53PC4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25025.2 GenPept UniProtKB/Swiss-Prot:P25025

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